WWD/REX/Shutterstock/Rex USA 1 / 50
WWD/REX/Shutterstock/Rex USA 1 / 50

Surviving divorce and a cancerous bone tumor in her youth, Kris Jenner grew up to become the matriarch and "momager" of TV’s most successful clan, the Kardashians, writer (Kardashian Konfidential and Kris Jenner ... And All Things Kardashian), boutique co-owner, host of a short-lived talk show (2013), and a reality star on Keeping Up with the Kardashians. Eschewing college, Jenner instead married successful attorney Robert Kardashian in 1978 and had son Rob and three daughters Kim, Kourtney, and Khloé before they divorced in 1989. She was devastated when her ex decided to represent his best friend O.J. Simpson when he was accused of killing her best friend Nicole. Kris remarried in 1991. She and Olympic gold medalist Bruce Jenner had two more daughters, Kendall and Kylie. In 2007, the show chronicling her family’s daily life began airing and over the years has given rise to various spinoffs like Kourtney and Kim Take Miami and Khloé and Lamar. In 2013, the Jenners announced their separation, divorced the following year and in 2015 the Olympian admitted that he was transgender and would be transitioning to living full-time as a woman. She has been dating road manager Corey Gamble since late 2014.