O'Reilly, 62, pointed out that the In the Land of Blood and Honey director "is a role model for some women" and suggested she might be sending the wrong message with her rail-thin appearance. "Something's going on here," O'Reilly said. "She is slight. Let's hope it's nothing unusual."
The political commentator wasn't the only one alarmed by Jolie's bony body.
During Sunday's telecast, Real Housewives of Atlanta star Phaedra Parks tweeted that Brad Pitt's love of seven years "is beautiful but she needs a lil' more meat on those bones!" The Bravo star then suggested that the mother-six eat "some biscuits and Popeyes chicken."
Singer-songwriter Bonnie McKee agreed with Parks, telling her Twitter followers that Jolie needs to "eat something."
Jolie's diminishing appearance first became a concern in December 2011, though a source close to the actress assured Us Weekly her pin-thin frame had little to do with vanity. "She puts herself on fasts to make statements for the children she visits," the source said of the U.N. goodwill ambassador. "She says, 'If they can't eat, I can't eat.'"