Juan Rico / Fame Pictures 1 / 6
Juan Rico / Fame Pictures 1 / 6

Chelsea Handler does not regret calling Angelina Jolie a "homewrecker" or an "f---ing b----" during a talked-about standup routine in Newark, NJ., over the weekend.

The comedian addressed the quasi-controversy on her late-night talk show "Chelsea Lately" on Monday night -- and suggested that her tirade against Jolie, 35, had absolutely nothing to do with Handler's close pal Jen Aniston.

"I've been making fun of Angelina Jolie since she made out with her brother!" Handler quipped. (Jolie famously locked lips with her brother James Haven at the Oscar ceremony in 2000, the year of Brad Pitt and Aniston's wedding; Jolie and Pitt hooked up about five years later.)

Maybe Handler should freshen up her routine, then? "If I've learned anything from this, it's to write some new jokes," she admitted.

During her Friday night show, which rumored beau 50 Cent watched in the wings, Handler dug into Jolie's famous brood of kids: "She can rescue as many babies from as many countries as she wants to ... I don't f---ing believe you."

More on Wonderwall:

Chelsea Handler's Foul-Mouthed Angelina Rant

Chelsea Handler hates being seen next to Jen Aniston in a bikini

What should Santa bring Angelina's brood?

More from UsWeekly:

PHOTOS: Jen's bikini body over the years

PHOTOS: Brad and Jen's years together

PHOTOS: All of Angelina's Us Weekly covers