"Two and a Half Men"'s Jon Cryer is officially throwing down the comedy gauntlet, writing a tongue-in-cheek "open letter" to his fellow Emmy nominee, "How I Met Your Mother" star Neil Patrick Harris.

"Hello Neil Patrick Harris. It's me, Jon Cryer, your worst nightmare," the funnyman's letter begins.

"Yes, that's right Neil Patrick Harris, the Television Academy has, once again, seen fit to nominate us both in their 'Outstanding Supporting Actor in a Comedy Series' category. Once again we will be joined in a battle of thespianism."

Cryer teasingly alludes to last year's Emmys, when he edged out Harris (who was also hosting the show) and four other nominees in the Outstanding Supporting Actor in a Comedy category.

"Will it be like last year, when you wowed the crowd with your singing and dancing, entertained them and made them laugh, showed them that, clearly, you possess more talent in your tiny little pinky than the whole body of that stupid Jon Cryer guy, only to be brutally disappointed when our category was announced?

"We'll see, Neil Patrick Harris, we'll see. My lack of talent has taken me this far and I'm betting it won't let me down again this year. Thankfully, the other gentlemen in this category are also supremely gifted. I'm a shoo-in!"

The 2010 Emmy Awards, hosted by "Late Night" host Jimmy Fallon, will air live from Los Angeles' Nokia Theatre August 29 on NBC.

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