Tonight on ABC it's a brand-new "Grey's Anatomy" and ET has the first words from Katherine Heigl's TV husband Justin Chambers since she confirmed that Izzy's out!

"Katherine is very much loved," Justin tells ET behind the scenes. "She's a huge part of the show's success."

Before he was called back to the set for doctor duty, he added: "She's always in our hearts and Izzy will always be a huge benefactor to the show."

Katherine made it official last week when she announced "I am done" with "Grey's Anatomy."

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