STR / Invision/AP 1 / 9
STR / Invision/AP 1 / 9

The chances of Madonna, 51, marrying 22-year-old beau Jesus Luz?

Not likely.

"I think I'd rather get run over by a train," she said on the Late Show With David Letterman Wednesday when asked her if she'd ever tie the knot again (see video, above).

She referred to her eight-year marriage to director Guy Ritchie as "the Bush years."

Sniped the singer, "It was a good time to be out of America."

When Letterman mentioned her ex-beau, New York Yankee Alex Rodriguez, Madonna rolled her eyes, but kept her sense of humor intact.

"Didn't you almost get arrested for bringing up A-Rod's name?" she cracked.

In June, Letterman famously came under fire for joking that the 14-year-old daughter of former Alaska Gov. Sarah Palin got pregnant by the slugger.

He told Madonna that he didn't get "arrested," but almost got "fired."

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