Johnny, 49, and Vanessa, 39, have reportedly been on separate paths for more than a year, living mainly apart despite both being based in Los Angeles, where their kids, Lily-Rose, 13, and Jack, 10, attend school.
Last month, Paradis was spotted checking out pricey properties (think $7 million to $11 million range) in Malibu and Beverly Hills, raising the question as to how much she stands to get in the split.
While the couple never married, the London Sun spitballs that the French actress could pocket in the tony neighborhood of $150 million. She'll also likely end up with the expansive villa Depp owns outside Paris.
"This won't be a monthly payment plan," one Hollywood lawyer speculates. "He will make a lump sum payment as a settlement."
So, what went wrong between the longtime partners? Theories range from boredom to another woman. Keep clicking for a breakdown of the rumor-mongering ...
RELATED: Johnny: A romance retrospective
Like us on Facebook?
UP NEXTKids' choice '15
From Crowd Ignite