Chelsea Handler flew solo at the awards after reportedly calling it quits with her boyfriend of nearly a year, hotelier André Balazs.
"She's fine," an insider assures the New York Post. "If she's feeling down, she's certainly not showing it."
The split apparently happened in just the last few days. Seems Chelsea and Andre appeared "very much together" when they attended a Halloween bash at one of his Manhattan properties.
Handler, who was previously linked to 50 Cent, was first spotted cozying up to Balazs at the Sundance Film Festival in January.
Meanwhile, Chelsea acknowledged how tough it is for women in Hollywood as she accepted her Queen of the Night prize.
"There are ... a lot of nos along the way," she said. "A lot of people who will tell you you can't do something or you're not good enough or you're not pretty enough or skinny enough or your butt's not as big as J.Lo's."
Concluded Handler, "I love women. I love supporting women. I love giving women jobs. I love being a woman and being a good friend and a sister, because I'll never be a mother!"