The daughter of actor John Drew Barrymore entered the family business at an early age. She was only 6 years old when she scored her first big break in "E.T. the Extra-Terrestrial." Though the Golden Globe winner struggled with alcohol and drug abuse during her teen years, she's gone on to become one of the most beloved actresses alive today. And when she's not entertaining us on the big screen, she's focused on expanding her family. The actress is expecting her second child with her hubby, Will Kopelman.