- Photo: ABC/Promotional6 of 8
5) The Meta Ending: Izzie comes back to the hospital and helps an ailing Jerry Bruckheimer with his appendicitis. As he comes to in his groggy state, he sees her walk out of the room and screams, "That girl! Get me that girl!" Izzie then goes to Hollywood and gets locked into a 20-year contract to replace Keira Knightley in the "Pirates" franchise.