Giuliana and Bill Rancic are about to become parents!

The couple's gestational carrier went into labor Wednesday, E! News confirmed.

PHOTOS: Giuliana and Bill's love story

"It's game time," Bill, 41, tweeted Wednesday. The first-time parents-to-be have spent the past week in Colorado anxiously awaiting the arrival of their son. To pass the time, Giuliana, 37, and Bill were enjoying a "babymoon" vacation by visiting local sights.

"Great hike on Vail Mountain, amazing couples massage . . . Now, this is how to spend a babymoon! Heaven," the mom-to-be tweeted Aug. 26.

PHOTOS: Stars who welcomed kids through surrogates

Once their son is born, the E! News anchor and motivational speaker/author will head to their home in Chicago first, before heading to Los Angeles in October.

The journey to becoming parents hasn't been easy for the Rancic family. The couple, who wed in September 2007, went through four, painful years of struggling to conceive, which included failed IVF treatments and a miscarriage. Late last summer, Giuliana was going to undergo another round of IVF when she was diagnosed with breast cancer. She decided to have a double mastectomy and is currently cancer free.

VIDEO: Giuliana and Bill reveal their hopes and dreams for their son

"We're so lucky. So many people have been pulling for us and following our journey," Bill recently told Us Weekly. "This has all been magical for us."

This article originally appeared on Giuliana, Bill Rancic's Surrogate Is In Labor!