Tiffany Rose / WireImage 1 / 2
Tiffany Rose / WireImage 1 / 2

Sarah Drew is pregnant -- again!

The "Grey's Anatomy" actress and her husband, Peter Lanfer, are expecting their second child together, her rep confirms to Us Weekly.

PHOTOS: Guess the baby bump

"Peter and I are delighted to announce our pregnancy," Drew, 33, tells Us in a statement. "We can't wait to introduce Micah to his little brother or sister."

PHOTOS: Hottest TV doctors

Drew -- who is due in December -- tied the knot with Lanfer in June 2002 and welcomed son Micah in January 2012. At the time, the star told Us how her "Grey's Anatomy" costars had helped her prep for her baby boy.

"I got great advice about nausea from Ellen Pompeo because I am still dealing with nausea, which is no fun," then-pregnant Drew told Us. "She's a wealth of information: She's done all the research and looked into every possible way of doing things."

PHOTOS: Celeb moms brag about their kids

"I've gotten some great advice from Jessica Capshaw, especially about the brand of Pampers I'm supposed to be using. But I'm like, 'Dude, I have some time,'" she added. "And I had great advice from Chyler Leigh about breastfeeding."

In March, Drew admitted in a Glamour interview that she and Lanfer have had their ups and downs. They received counseling during their "blackest time," but clearly seem to be better than ever.

PHOTOS: Everwood and other reunions

"He's become super protective of my energy level and time," the Everwood alum added to Us in 2012. "He's been amazing. I can't ask for a better partner."