While appearing on Stars In The House with his former co-stars for a cast reunion, George said Amal really disapproves of his character's antics and keeps wondering when he's going to grow up.
"This has been a very, very disastrous thing for me because I forgot all of the terrible things I'd done as Dr. Ross!" George said. "My wife keeps going, 'Is that it? Are you done? Season 3 – do you finally settle down with Nurse Hathaway?' It's been a disaster for my marriage."
The drama really helped launch George's career, as he's gone on to become one of the biggest names in entertainment. Still, he holds the show in high regard and is against a revival, as he's unsure if the cast could ever meet the high bar that he feels they set in the '90s.
"When you look at the show, it'd be hard to say that we could do it [again] at the level that we did it," he said. "Because boy, I've actually been watching it a bit because my wife's been watching it, which is very odd, and I have to say, it's such great television."
George's "ER" love interest Julianna Marguiles agreed.
"I don't think you can reboot it," she said. "I think it's what George said – you can't capture lightning in a bottle twice. I think you have to leave what was so beautiful and move on. It feels like it would cheapen it for me."