Joseph Marzullo / WENN 1 / 6
Joseph Marzullo / WENN 1 / 6

Mary Tyler Moore, a mainstay on TV in the 60s and 70s, has died at the age of 80 in a Connecticut hospital.

Her rep confirmed the news with a statement on Wednesday, Jan. 25.

"Today, beloved icon, Mary Tyler Moore, passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine," Mary's rep said. "A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile."

The death came after a report that she was in "grave condition" and had been on a respirator for more than a week.

TMZ claimed that family members said their final goodbyes.

Her health struggles had long been chronicled -- she's battled diabetes and she underwent brain surgery in 2011. She also wrote about dealing with alcoholism in her memoir "After All," released in 1995.

The 80-year-old portrayed a spunky Minneapolis newswoman on "The Mary Tyler Moore Show" from 1970-1977. Prior to that, she had an Emmy and Golden Globe-winning role in "The Dick Van Dyke Show."

"I think Mary Tyler Moore has had more influence on my career than any other single person or force," Oprah Winfrey said last year in a PBS documentary celebrating the Mary's self-titled show.

The funny lady is responsible for one of the most iconic images in TV history. At the end of the opening credits of her show, Mary tosses a knit hat in the air after long day of shopping while the theme song says, "We're gonna make it after all."

In 1999, Entertainment Weekly said the shot was the second greatest moment in TV history in the 70s, behind only the assassination and funeral of John F. Kennedy.

"In addition to putting a perfect, um, cap on her signature show's opening credits, the gesture also spoke volumes about Moore's new-gal-in-town character, Mary Richards," the magazine said.

At the time, the actress spoke to EW about that hat-tossing moment.

"Wasn't it great?" she said. "Freedom, exuberance, spontaneity, joy — all in that one gesture. It gave a hint at what you were going to see."