AXELLE WOUSSEN/Bauer-Griffin 1 / 15
AXELLE WOUSSEN/Bauer-Griffin 1 / 15

James Franco has a new task on his mile-long to-do list: Get a new girlfriend.

The industrious actor, writer, artist and student has parted ways with Ahna O'Reilly, his actress girlfriend of five years.

PHOTOS: Big-time splits in Hollywood

"It's over," Franco, 33, admits in the August issue of Playboy (excerpted in the New York Daily News). In addition to his busy movie career, the "Rise of the Planet of the Apes" star has famously been pursuing multiple degrees at Yale, NYU, Columbia and other schools -- not to mention a stint on TV soap "General Hospital."

PHOTOS: What James and all the stars wore at the 2011 Oscars

"We'd been living together in L.A. and then came to New York to go school for two years," Franco says of O'Reilly. "Then I signed up for more school at Yale. I think that was it for her."

Before he and O'Reilly began dating in 2006, Franco romanced actress Marla Sokoloff. He has also been romantically linked to Sienna Miller.

PHOTOS: Hollywood's hunkiest stars

O'Reilly has appeared in films like "Forgetting Sarah Marshall," and this summer's "The Help," plus TV's "CSI: NY" and "The Vampire Diaries."