Sorry, Jennifer Aniston: David Arquette is off-limits!
During a candid interview on Howard Stern's SiriusXM radio show Thursday, Courteney Cox admitted she would "freak out" if her longtime BFF and former Friends costar ever got romantic with her estranged hubby, 39.
"That would just hurt me, because I have a real thing about friends," the 46-year-old Scream 4 actress explained. "She's one of my very best friends, so that would be weird."
Not that Cox believes Aniston, 42, would ever dream of pursuing a relationship with Arquette. "I would think that she cares too much about me to let that happen," Cox added.
After all, Stern said, Arquette has his eye on a much-younger star: up-and-coming singer Jessie J., 23.
Though Arquette claimed the pop star is "too young" for him, an unconvinced Cox warned: "I'll be looking her up later. Don't you worry."
Meanwhile, Cox -- who denied romancing her Cougar Town costars Josh Hopkins and Brian van Holt -- revealed she has "not had sex" since announcing their separation last fall.