By Isabella Torregiani
1:34pm PST, Feb 25, 2026
_
Since her 2021 multiple sclerosis (MS) diagnosis,
Christina Applegate's life has been turned upside down. Now largely confined to her bed by chronic pain, the actress has opened up about how she's navigating her new reality.
See how she's managing her new normal…MORE:
Follow Wonderwall on MSN for more top news
_
Despite the major changes brought on by her diagnosis,
Christina Applegate still prioritizes helping her 15-year-old daughter, Sadie, shared with husband
Martyn LeNoble, get to school and activities.
"I want to take her; it's my favorite thing to do. It's the only time we have together by ourselves," Applegate told
People.
"I tell myself, 'Just get her there safely and get home so you can get back into bed.' And that's what I do," she added.
_
Christina Applegate explained that being largely confined to her bedroom has given her the space to share her journey with complete honesty.
"My life isn't wrapped up with a bow," said Applegate, who co-hosts the "MeSsy" podcast with fellow actress
Jamie-Lynn Sigler (who also has MS).
"People's lives, sorry for lack of a better term, f****** suck sometimes. So I'm being as honest and raw as I possibly can," she added.
_
That journey begins with her new memoir,
You With the Sad Eyes, which covers
Christina Applegate's upbringing in L.A.'s Laurel Canyon, teen fame, abusive relationships, motherhood and her experiences with both breast cancer and MS.
"We all have come from somewhere, some places more painful than others, and it's what you do with it, I guess," said the star. "This is not an inspirational book, by any means. But it can inspire."
_
Christina Applegate, who is launching the online platform Next in MS for others to share their experiences with the disease, said that writing her memoir wasn't exactly healing.
"It's about a little girl with sad eyes who ended up becoming
Christina Applegate. And she still has those sad eyes. But she's a stronger, different, resilient human being. And that's really kind of my story," she explained.
