Former child star Fred Savage is in negotiations to direct Charlize Theron in the comedy "Ladies Night."

David Ellison's Skydance Productions is financing the film, which is being eyed as an early 2014 production.

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The project represents another major jump in the unlikely career evolution of Savage, a one-time child actor who has morphed into one of Hollywood's hottest TV directors. The "Wonder Years" star is bucking the trend of child actors with downward career trajectories and instead is following in the footsteps of Ron Howard, Jodie Foster and Brian Robbins, who became big-screen directors working with A-list talent.

The "Bridesmaids"-esque comedy also marks a departure for Theron, who rarely works in the genre (though she recently signed on for the Seth MacFarlane comedy "A Million Ways to Die in the West"). Theron will star in and produce "Ladies Night," which centers on a woman who, when confronted with her longtime boyfriend's inability to commit, decides to have one last night on the town with her girlfriends before uprooting her life and moving to New York.

Savage made his big-screen directing debut with the 2007 comedy "Daddy Day Camp." His TV helming credits include "Modern Family" and "2 Broke Girls."