Sykes, who currently co-stars on CBS' "The New Adventures of Old Christine," will launch her show in the fall, the showbiz trade papers say. The show would air at 11 p.m. ET on Saturdays, taking over the spot currently occupied by "MadTV," which is in its final season.
What the new show might mean for the network's other late-Saturday offering, "Talkshow with Spike Feresten," is unclear. Feresten's show, which airs at midnight, got a trial run in the 11 p.m. slot earlier this season, but its fate for 2009-10 is still undetermined.
Details of Sykes' show are still being worked out, but it's expected to be a panel show more along the lines of HBO's "Real Time with Bill Maher" more than a traditional couch-and-desk talk show. Sykes would also do taped pieces.
Sykes starred in the FOX sitcom "Wanda at Large," which had a brief run in 2003. Her credits also include a recurring part on "Curb Your Enthusiasm," "Evan Almighty" and "Monster-in-Law."