David Arquette comes from a well-known family of actors, stretching all the way back to his vaudevillian great-grandfather and including his older siblings Patricia, Alexis, Rosanna and Richmond. Born on a commune but raised mostly in LA, he auditioned for several years to no avail. His first break was landing the lead in the short-lived 1990 TV series “The Outsiders,” but it like most of his early gigs (the first TV attempt at “Parenthood” and 1995’s “Double Rush”), didn’t last past season 1. He had better luck taking quirky parts in feature films like “Buffy The Vampire Slayer,” “Wild Bill,” and “Beautiful Girls.” He went mainstream but stayed quirky in 1996’s “Scream,” where he met his future wife Courteney Cox, and "Never Been Kissed" (1999). After marrying Cox in 1999, the duo formed a production company and worked together on several projects including the drama “Cougar Town” and “Dirt.” and He served as a producer and director for "Dirt," which provided him valuable experience when writing and directing the satirical horror film “Tripper” in 2007. He and Cox, who had daughter Coco in 2004, split in 2010 after he had an affair. On a happier note, he welcomed son Charlie with girlfriend Christina McLarty in April 2014.