Comic Tig Notaro stunned fans at a stand-up gig on Friday when she announced she is fighting cancer.

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The 41-year-old star, who has appeared on "The Sarah Silverman Program," kicked off her set at Los Angeles' Largo comedy club by working her diagnosis into her material.

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As she stepped onstage to applause, she told the crowd, "Thank you, thank you, I have cancer, thank you, I have cancer, really, thank you."

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She then added, "Tragedy plus time equals comedy. But I don't have the benefit of time. So I'm just going to tell you the tragedy and know that everything is going to be OK."

Notaro received a standing ovation at the end of her moving set and comic Louis CK tweeted, "in 27 years doing this, I've seen a handful of truly great, masterful standup sets. One was Tig Notaro last night at Largo."