Why he's nominated: For playing lonely businessman Ryan Bingham, who realizes that it's actually the human connections that matter most in life.
Chances of winning: 4-1. Let's face it: The world just loves George Clooney. The Academy is not exempt from this rule, evidenced by the fact that his lead and supporting actresses also scored nominations this year. Not that he's solely to thank, but it definitely didn't hurt Anna Kendrick and Vera Farmiga to share screen time with Clooney. As good as all the Best Actor nominees are, it seems like 2010 might be the year to play a suave businessman with a heartwarming character arc.