By Molly Goddard
4:34am PDT, Jun 4, 2025
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Leonardo DiCaprio's recently slimmed-down appearance has experts pointing the finger at Ozempic.
"[He] looks visibly less bloated and appears slimmer. While it certainly could be from diet and exercise alone and minimizing his intake of alcohol, it could also be by the assistance of a GLP-1 medication such as Ozempic,"
Chris Bustamante DNP, NP-C, and founder of
Lushful Aesthetics told OK!
in a June 3 exclusive, adding that the Oscar winner "is looking great!"
Meanwhile,
Dr. Konstantin Vasyukevich — a double board-certified facial plastic surgeon in New York City — pointed out that the actor (he's pictured at CinemaCon in April) has experienced significant "volume loss in his facial features, particularly in the cheeks and mid-face region" since last year.
"These changes are often consistent with overall weight reduction, which can occur gradually due to lifestyle changes or more rapidly with the assistance of medications such as Ozempic,"
he told OK, adding that "this type of facial transformation is not uncommon and tends to reflect the broader effects of weight loss on soft tissue volume."
Fans have also commented on DiCaprio's apparent weight-loss: "He looks remarkably healthier and less bloated and red in the face," one fan wrote on Reddit, while another speculated that the
Titanic alum "looks like he's joined the Ozempic bandwagon."
A source close to DiCaprio previously noted that while he's lost weight before, "this time it's different because it's not for a movie role." The source claimed that the former child star is getting fit to "keep up" with
his much-younger girlfriend, Vittoria Ceretti. "She has a big influence on him," the insider said before clarifying that the model was "by no means repelled by the way he looked before."
Keep reading for more of the year's best celeb body moments…MORE:
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Jason Biggs is opening up about his major weight loss.
The
American Pie actor revealed he dropped 35 pounds over about a year: "I had some cholesterol issues. Probably because of the ice cream pints I would knock back," he told
Page Six on April 22. "It's been a journey. My cholesterol came down 70 points."
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Meghan Trainor showed off her fit physique while stepping out at the 2025 Billboard Women in Music event in March.
"I learned a lot of tricks that I had no idea [about]," the pop star told
Entertainment Tonight about her health journey while walking the red carpet. "I was working out so incorrectly for so long. I was running and doing cardio and my body was inflamed, always." She later fessed up to also using the weight-loss drug Mounjaro.
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Lizzo has been open with her fans about how she transformed her body. In January, the "Truth Hurts" singer revealed she'd reached her desired weight.
"I did it," she wrote on Instagram. "Today when I stepped on my scale, I reached my weight release goal. I haven't seen this number since 2014! Let this be a reminder you can do anything you put your mind to. Time for new goals!"
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Remi Bader's weight-loss journey caused a stir on social media after she revealed she underwent bariatric surgery to help her shed some pounds after previously attributing her transformation to just diet and exercise.
"Don't let anyone ever tell you surgery is the easy way out. I worked hard to get here and I'm forever proud of myself," the influencer captioned a video of herself working out on Instagram.
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Channing Tatum took to Instagram in March to open up about getting in shape for the characters he plays.
"We back up! lol. 1st photo is today 205. 2nd photo 235 for a movie called
Josephine," he captioned a slideshow of three photos of his different physiques. "Then went to 3rd photo which is 172 for a movie
Roofman. I'm so grateful for my genetics. Grateful for my chef/nutritionist/witch. Grateful for my trainer. I couldn't make these big swings in my weight without you guys. But I won't be doing anymore [overweight] roles haha. It's to hard on the body and [too] hard to take off now. But d*** when I look at these pics it's just wild what the human body and will can do."
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In February,
Queer Eye's
Jonathan Van Ness took to Instagram to let their fans in on how they dropped 66 lb: "I want to note, GLP-1s have been a huge help," the reality star made clear about using the controversial weight-loss medication.
"I have also made major other changes," Van Ness continued. "First was my diet obvs, second was way less alcohol and finally group Pilates which has been most pivotal. My mental health and overall feeling is a different universe since last year and the biggest change was group fitness."
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In early April,
Peirce Brosnan's wife,
Keely Shaye Smith, showed off her slimmed-down figure at the opening night of
Good Night, and Good Luck on Broadway.
Despite undergoing a transformation, the journalist has never shied away from showing off her body. "I never shy away from … my curves. I never hide in baggy clothing," she told
Vogue in 2006.
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This Is Us star
Chrissy Metz revealed she lost 100 pounds over the last year. "I have always enjoyed strength training. I've always enjoyed lifting weights, like I don't want to run unless I'm being chased," she told
DailyMail.com in April. "I want to age the best way that I can, and I want to be strong. And that's really the impetus behind any of it."
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Gypsy-Rose Blanchard took to social media in mid-April to share
a selfie showing off her major health milestone.
"My 25lbs weight loss," she captioned a side-by-side comparison on Instagram.
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Singer
Jelly Roll made some major changes in his life for 2025 after revealing he's down 180 pounds.
During an appearance on
Pat McAfee's live show in Penn., the star revealed, "I started at 540 pounds. I'm 357 pounds this morning, baby. I'm going to lose another 100 pounds and go skydiving with my wife in Sweden, baby."
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Cardi B took to Instagram in January to share a video of herself dancing and highlighting her toned figure. "I lost sooo much weight," the rapper wrote alongside the clip.
